FIGURE

Fig. 4

ID

ZDB-FIG-080923-22

Publication

Marques et al., 2008 - Reiterative roles for FGF signaling in the establishment of size and proportion of the zebrafish heart

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Fig. 4

Heat shock of Tg(hsp70:ca-fgfr1) embryos causes ectopic FGF signaling and perturbs pectoral fin development. (A, B) In situ hybridization depicts pea3 expression at 32 hpf; dorsal views, anterior to the left. (A) After heat shock at 24 hpf, non-transgenic (non-tg) embryos show a wild-type restriction of pea3 expression to specific regions, including the midbrain–hindbrain boundary and the pharyngeal pouches. (B) In contrast, heat shock of transgenic (tg) embryos causes strong and ectopic expression of pea3. (C, D) Dorsal views at 72 hpf of embryos after heat shock at the 8-somite stage. (C) Non-transgenic embryos exhibit pectoral fins of normal length (bar). (D) Transgenic embryos lack at least one pectoral fin, as shown here (n = 14/50), or have two small fins (n = 31/50).

Expression Data

Gene:	etv4
Fish:	WT pd3Tg
Condition:	heat shock
Anatomical Terms:	midbrain hindbrain boundary pharyngeal pouch whole organism
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 321(2), Marques, S.R., Lee, Y., Poss, K.D., and Yelon, D., Reiterative roles for FGF signaling in the establishment of size and proportion of the zebrafish heart, 397-406, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.