ZFIN ID: ZDB-LAB-170214-10
Chengtian Zhao Lab
PI/Director: Zhao, Chengtian
Contact Person: Zhao, Chengtian
Email: Chengtian_zhao@ouc.edu.cn
URL: http://iemb.ouc.edu.cn/18974/list.htm
Address: Laboratory of Cilia Biology & Organogenesis Institute of Evolution & Marine Biodiversity Ocean University of China 5 Yushan Road Qingdao 266003 China
Country: China
Phone: 86-532-82032962, 86-532-82032173
Fax:
Line Designation: ouc


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 33 genomic features


STATEMENT OF RESEARCH INTERESTS
Cilia exist in many phyla from protozoa to mammalian cells and play diverse biological functions. Disruption in cilia function has been linked to many human genetic disorders, collectively termed as ciliopathies. Our lab is interested in the study of mechanisms underlying ciliogenesis using multiple organisms, including zebrafish, placozoa and ciliates. Currently, the main focus of our lab include: 1) The mechanisms of body axis development regulated by cilia-driven cerebrospinal fluid; 2) Degeneration and renewal of photoreceptor cells; 3) Role of cilia and ciliary genes in ciliopathies; 4) Functional evolution of cilia.


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Xie, H., Kang, Y., Liu, J., Huang, M., Dai, Z., Shi, J., Wang, S., Li, L., Li, Y., Zheng, P., Sun, Y., Han, Q., Zhang, J., Zhu, Z., Xu, L., Yelick, P.C., Cao, M., Zhao, C. (2023) Ependymal polarity defects coupled with disorganized ciliary beating drive abnormal cerebrospinal fluid flow and spine curvature in zebrafish. PLoS Biology. 21:e3002008e3002008
Zhu, P., Zheng, P., Kong, X., Wang, S., Cao, M., Zhao, C. (2022) Rassf7a promotes spinal cord regeneration and controls spindle orientation in neural progenitor cells. EMBO reports. 24(1):e54984
Xie, H., Wang, X., Jin, M., Li, L., Zhu, J., Kang, Y., Chen, Z., Sun, Y., Zha, C. (2022) Cilia regulate meiotic recombination in zebrafish. Journal of molecular cell biology. 14(7)
Jin, X., Liu, J., Wang, S., Shi, J., Zhao, C., Xie, H., Kang, Y. (2022) E2f4 is required for intestinal and otolith development in zebrafish. Journal of Cellular Physiology. 237(6):2690-2702
Zhu, P., Xu, J., Wang, Y., Zhao, C. (2021) Loss of Ift74 Leads to Slow Photoreceptor Degeneration and Ciliogenesis Defects in Zebrafish. International Journal of Molecular Sciences. 22(17):
Zhao, L., Xie, H., Kang, Y., Lin, Y., Liu, G., Sakato-Antoku, M., Patel-King, R.S., Wang, B., Wan, C., King, S.M., Zhao, C., Huang, K. (2021) Heme-binding protein CYB5D1 is a radial spoke component required for coordinated ciliary beating. Proceedings of the National Academy of Sciences of the United States of America. 118(17):
Luo, M., Lin, Z., Zhu, T., Jin, M., Meng, D., He, R., Cao, Z., Shen, Y., Lu, C., Cai, R., Zhao, Y., Wang, X., Li, H., Wu, S., Zou, X., Luo, G., Cao, L., Huang, M., Jiao, H., Gao, H., Sui, R., Zhao, C., Ma, X., Cao, M. (2021) Disrupted intraflagellar transport due to IFT74 variants causes Joubert syndrome. Genetics in medicine : official journal of the American College of Medical Genetics. 23(6):1041-1049
Wang, X., Wang, S., Meng, Z., Zhao, C. (2020) Adrb1 and Adrb2b are the major β-adrenergic receptors regulating body axis straightening in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 47(12):781-784
Zhang, H., Rong, X., Wang, C., Liu, Y., Lu, L., Li, Y., Zhao, C., Zhou, J. (2020) VBP1 modulates Wnt/β-catenin signaling by mediating the stability of the transcription factors TCF/LEFs. The Journal of biological chemistry. 295(49):16826-16839
Xie, H., Kang, Y., Wang, S., Zheng, P., Chen, Z., Roy, S., Zhao, C. (2020) E2f5 is a versatile transcriptional activator required for spermatogenesis and multiciliated cell differentiation in zebrafish. PLoS Genetics. 16:e1008655
Kang, Y., Xie, H., Zhao, C. (2019) Ankrd45 Is a Novel Ankyrin Repeat Protein Required for Cell Proliferation. Genes. 10(6)
Liu, Z., Tu, H., Kang, Y., Xue, Y., Ma, D., Zhao, C., Li, H., Wang, L., Liu, F. (2019) Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish. Nature communications. 10:1839
Zhang, X., Jia, S., Chen, Z., Chong, Y.L., Xie, H., Feng, D., Wu, X., Song, D.Z., Roy, S., Zhao, C. (2018) Cilia-driven cerebrospinal fluid flow directs expression of urotensin neuropeptides to straighten the vertebrate body axis. Nature Genetics. 50(12):1666-1673
Han, X., Xie, H., Wang, Y., Zhao, C. (2018) Radial spoke proteins regulate otolith formation during early zebrafish development. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(7):3984-3992
Feng, D., Chen, Z., Yang, K., Miao, S., Xu, B., Kang, Y., Xie, H., Zhao, C. (2017) The cytoplasmic tail of rhodopsin triggers rapid rod degeneration in kinesin-2 mutants. The Journal of biological chemistry. 292(42):17375-17386
Rong, X., Zhou, Y., Liu, Y., Zhao, B., Wang, B., Wang, C., Gong, X., Tang, P., Lu, L., Li, Y., Zhao, C., Zhou, J. (2017) Glutathione peroxidase 4 inhibits Wnt/β-catenin signaling and regulates dorsal organizer formation in zebrafish embryos. Development (Cambridge, England). 144(9):1687-1697
Song, Z., Zhang, X., Jia, S., Yelick, P.C., Zhao, C. (2016) Zebrafish as a Model for Human Ciliopathies. Journal of genetics and genomics = Yi chuan xue bao. 43:107-20
Zhao, C., Andreeva, V., Gibert, Y., LaBonty, M., Lattanzi, V., Prabhudesai, S., Zhou, Y., Zon, L., McCann, K.L., Baserga, S., and Yelick, P.C. (2014) Tissue specific roles for the ribosome biogenesis factor Wdr43 in zebrafish development. PLoS Genetics. 10(1):e1004074
Zhao, C., Omori, Y., Brodowska, K., Kovach, P., and Malicki, J. (2012) Kinesin-2 family in vertebrate ciliogenesis. Proceedings of the National Academy of Sciences of the United States of America. 109(7):2388-2393
Zhao, C., and Malicki, J. (2011) Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos. The EMBO journal. 30(13):2532-2544
Zhao, C., Wang, X., Zhao, Y., Li, Z., Lin, S., Wei, Y., and Yang, H. (2011) A novel xenograft model in zebrafish for high-resolution investigating dynamics of neovascularization in tumors. PLoS One. 6(7):e21768
Zhao, C., and Malicki, J. (2007) Genetic defects of pronephric cilia in zebrafish. Mechanisms of Development. 124(7-8):605-616
Zhao, C., He, X., Tian, C., and Meng, A. (2006) Two GC-rich boxes in huC promoter play distinct roles in controlling its neuronal specific expression in zebrafish embryos. Biochemical and Biophysical Research Communications. 342(1):214-220
Zhao, C., Qi, J., and Meng, A. (2005) Characterization and expression pattern of two zebrafish atf7 genes. Developmental Dynamics : an official publication of the American Association of Anatomists. 233(3):1157-1162
Zhao, C., and Meng, A. (2005) Sp1-like transcription factors are regulators of embryonic development in vertebrates. Development, growth & differentiation. 47(4):2001-211
Penberthy, W.T., Zhao, C., Zhang, Y., Jessen, J.R., Yang, Z., Bricaud, O., Collazo, A., Meng, A., and Lin, S. (2004) Pur alpha and Sp8 as opposing regulators of neural gata2 expression. Developmental Biology. 275(1):225-234
Zhao, J., Cao, Y., Zhao, C., Postlethwait, J., and Meng, A. (2003) An SP1-like transcription factor Spr2 acts downstream of Fgf signaling to mediate mesoderm induction. The EMBO journal. 22(22):6078-6088