ZFIN ID: ZDB-LAB-150714-1
Jean Giacomotto Lab
PI/Director: Giacomotto, Jean
Contact Person: Giacomotto, Jean
Email: j.giacomotto@griffith.edu.au
URL: https://giacomottolab.com/
Address: Griffith Institute for Drug Discovery | Discovery Biology Griffith University | Nathan Campus | QLD 4111 https://www.griffith.edu.au/gridd https://www.discoverybiology.org/ https://giacomottolab.com/
Country: Australia
Phone: +61 423071651
Fax:
Line Designation: uq


GENOMIC FEATURES ORIGINATING FROM THIS LAB
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STATEMENT OF RESEARCH INTERESTS


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Hall, T.E., Ariotti, N., Lo, H.P., Rae, J., Ferguson, C., Martel, N., Lim, Y.W., Giacomotto, J., Parton, R.G. (2023) Cell surface plasticity in response to shape change in the whole organism. Current biology : CB. 33(19):4276-4284.e4
Tromp, A., Wang, H., Hall, T.E., Mowry, B., Giacomotto, J. (2023) Optimising the zebrafish Cre/Lox toolbox. Codon improved iCre, new gateway tools, Cre protein and guidelines. Frontiers in Physiology. 14:12213101221310
Marquez-Legorreta, E., Constantin, L., Piber, M., Favre-Bulle, I.A., Taylor, M.A., Blevins, A.S., Giacomotto, J., Bassett, D.S., Vanwalleghem, G.C., Scott, E.K. (2022) Brain-wide visual habituation networks in wild type and fmr1 zebrafish. Nature communications. 13:895
Restuadi, R., Steyn, F.J., Kabashi, E., Ngo, S.T., Cheng, F.F., Nabais, M.F., Thompson, M.J., Qi, T., Wu, Y., Henders, A.K., Wallace, L., Bye, C.R., Turner, B.J., Ziser, L., Mathers, S., McCombe, P.A., Needham, M., Schultz, D., Kiernan, M.C., van Rheenen, W., van den Berg, L.H., Veldink, J.H., Ophoff, R., Gusev, A., Zaitlen, N., McRae, A.F., Henderson, R.D., Wray, N.R., Giacomotto, J., Garton, F.C. (2022) Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1. Genome Medicine. 14:7
Lo, H.P., Lim, Y.W., Xiong, Z., Martel, N., Ferguson, C., Ariotti, N., Giacomotto, J., Rae, J., Floetenmeyer, M., Moradi, S.V., Gao, Y., Tillu, V.A., Xia, D., Wang, H., Rahnama, S., Nixon, S.J., Bastiani, M., Day, R.D., Smith, K.A., Palpant, N.J., Johnston, W.A., Alexandrov, K., Collins, B.M., Hall, T.E., Parton, R.G. (2021) Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle. The Journal of cell biology. 220(12)
Tromp, A., Robinson, K., Hall, T.E., Mowry, B., Giacomotto, J. (2021) Pipeline for generating stable large genomic deletions in zebrafish, from small domains to whole gene excisions. G3 (Bethesda). 11(12):
Butti, Z., Pan, Y.E., Giacomotto, J., Patten, S.A. (2021) Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish. Communications biology. 4:792
Gormal, R.S., Padmanabhan, P., Kasula, R., Bademosi, A.T., Coakley, S., Giacomotto, J., Blum, A., Joensuu, M., Wallis, T.P., Lo, H.P., Budnar, S., Rae, J., Ferguson, C., Bastiani, M., Thomas, W.G., Pardon, E., Steyaert, J., Yap, A.S., Goodhill, G.J., Hilliard, M.A., Parton, R.G., Meunier, F.A. (2020) Modular transient nanoclustering of activated β2-adrenergic receptors revealed by single-molecule tracking of conformation-specific nanobodies. Proceedings of the National Academy of Sciences of the United States of America. 117:30476-30487
Wang, D., Himaya, S.W.A., Giacomotto, J., Hasan, M.M., Cardoso, F.C., Ragnarsson, L., Lewis, R.J. (2020) Characterisation of d-Conotoxin TxVIA as a Mammalian T-Type Calcium Channel Modulator. Marine drugs. 18(7)
Dutt, M., Giacomotto, J., Ragnarsson, L., Andersson, Å., Brust, A., Dekan, Z., Alewood, P.F., Lewis, R.J. (2019) The α1-adrenoceptor inhibitor ρ-TIA facilitates net hunting in piscivorous Conus tulipa. Scientific Reports. 9:17841
Periyasamy, S., John, S., Padmavati, R., Rajendren, P., Thirunavukkarasu, P., Gratten, J., Vinkhuyzen, A., McRae, A., Holliday, E.G., Nyholt, D.R., Nancarrow, D., Bakshi, A., Hemani, G., Nertney, D., Smith, H., Filippich, C., Patel, K., Fowdar, J., McLean, D., Tirupati, S., Nagasundaram, A., Gundugurti, P.R., Selvaraj, K., Jegadeesan, J., Jorde, L.B., Wray, N.R., Brown, M.A., Suetani, R., Giacomotto, J., Thara, R., Mowry, B.J. (2019) Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study. JAMA psychiatry. 76(10):1026-1034
Lim, Y.W., Lo, H.P., Ferguson, C., Martel, N., Giacomotto, J., Gomez, G.A., Yap, A.S., Hall, T.E., Parton, R.G. (2017) Caveolae Protect Notochord Cells against Catastrophic Mechanical Failure during Development. Current biology : CB. 27(13):1968-1981.e7
Giacomotto, J., Carroll, A.P., Rinkwitz, S., Mowry, B., Cairns, M.J., Becker, T.S. (2016) Developmental suppression of schizophrenia-associated miR-137 alters sensorimotor function in zebrafish. Translational psychiatry. 6:e818
Laird, A.S., Mackovski, N., Rinkwitz, S., Becker, T.S., Giacomotto, J. (2016) Tissue-specific models of spinal muscular atrophy confirm a critical role of SMN in motor neurons from embryonic to adult stages. Human molecular genetics. 25(9):1728-38
Svahn, A.J., Giacomotto, J., Graeber, M.B., Rinkwitz, S., Becker, T.S. (2016) miR-124 contributes to the functional maturity of microglia. Developmental Neurobiology. 76(5):507-18
Ishibashi, M., Manning, E., Shoubridge, C., Krecsmarik, M., Hawkins, T.A., Giacomotto, J., Zhao, T., Mueller, T., Bader, P.I., Cheung, S.W., Stankiewicz, P., Bain, N.L., Hackett, A., Reddy, C.C., Mechaly, A.S., Peers, B., Wilson, S.W., Lenhard, B., Bally-Cuif, L., Gecz, J., Becker, T.S., Rinkwitz, S. (2015) Copy number variants in patients with intellectual disability affect the regulation of ARX transcription factor gene. Human genetics. 134(11-12):1163-82
Himaya, S.W., Jin, A.H., Dutertre, S., Giacomotto, J., Mohialdeen, H., Vetter, I., Alewood, P.F., Lewis, R.J. (2015) Comparative venomics reveals the complex prey capture strategy of the piscivorous cone snail Conus catus. Journal of Proteome Research. 14(10):4372-81
Giacomotto, J., Rinkwitz, S., Becker, T.S. (2015) Effective heritable gene knockdown in zebrafish using synthetic microRNAs. Nature communications. 6:7378
Punnamoottil, B., Rinkwitz, S., Giacomotto, J., Svahn, A.J., Becker, T.S. (2015) Motor neuron-expressed microRNAs 218 and their enhancers are nested within introns of SLIT2/3 genes. Genesis (New York, N.Y. : 2000). 53(5):321-8
Giacomotto, J., Brouilly, N., Walter, L., Mariol, M.C., Berger, J., Ségalat, L., Becker, T.S., Currie, P.D., and Gieseler, K. (2013) Chemical genetics unveils a key role of mitochondrial dynamics, cytochrome c release and IP3R activity in muscular dystrophy. Human molecular genetics. 22(22):4562-78
Djiotsa, J., Verbruggen, V., Giacomotto, J., Ishibashi, M., Manning, E., Rinkwitz, S., Manfroid, I., Lvoz, M., and Peers, B. (2012) Pax4 is not essential for beta-cell differentiation in zebrafish embryos but modulates alpha-cell generation by repressing arx gene expression. BMC Developmental Biology. 12(1):37
Giacomotto, J., and Ségalat, L. (2010) High-throughput screening and small animal models, where are we?. British journal of pharmacology. 160(2):204-216