ZFIN ID: ZDB-LAB-010227-1
Kinsey Lab
PI/Director: Kinsey, William H.
Contact Person: Kinsey, William H.
Email: wkinsey@kumc.edu
URL: http://www.kumc.edu
Address: Department of Anatomy & Cell Biology University of Kansas Medical Center 3901 Rainbow Boulevard Kansas City, KS 66160 USA
Country: United States
Phone: (913) 588-2721
Fax: (913) 588-2710
Line Designation: ku


GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available


STATEMENT OF RESEARCH INTERESTS
Biochemical analysis of signal transduction events involved in fertilization and early egg activation. Role of Src family protein tyrosine kinases in initiation of development. Most of our work has been on the c-Fyn tyrosine kinase. We are interested in the role of this kinase in calcium mobilization following fertilization, and the mechanism by which the kinase itself is regulated.


LAB MEMBERS
Wu, Wen-Jun Post-Doc


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Luo, J., McGinnis, L.K., Carlton, C., Beggs, H.E., Kinsey, W.H. (2014) PTK2b function during fertilization of the mouse oocyte. Biochemical and Biophysical Research Communications. 450(3):1212-7
Kinsey, W.H. (2013) Intersecting roles of protein tyrosine kinase and calcium signaling during fertilization. Cell Calcium. 53(1):32-40
Sharma, D., and Kinsey, W.H. (2013) PYK2: A calcium-sensitive protein tyrosine kinase activated in response to fertilization of the zebrafish oocyte. Developmental Biology. 373(1):130-140
Kinsey, W.H. (2009) Analysis of signaling pathways in zebrafish development by microinjection. Methods in molecular biology (Clifton, N.J.). 518:1-10
Sharma, D., and Kinsey, W.H. (2008) Regionalized calcium signaling in zebrafish fertilization. The International journal of developmental biology. 52(5-6):561-570
Sharma, D., and Kinsey, W.H. (2006) Fertilization triggers localized activation of Src-family protein kinases in the zebrafish egg. Developmental Biology. 295(2):604-614
Sharma, D., Holets, L., Zhang, X., and Kinsey, W.H. (2005) Role of Fyn kinase in signaling associated with epiboly during zebrafish development. Developmental Biology. 285(2):462-476
Tsai, W.B., Zhang, X., Sharma, D., Wu, W., and Kinsey, W.H. (2005) Role of Yes kinase during early zebrafish development. Developmental Biology. 277(1):129-141
MacGregor, E., and Kinsey, W.H. (2004) Single-cell method for estimation of protein tyrosine kinases in the zebrafish egg. Methods in molecular biology (Clifton, N.J.). 253:285-292
Wu, W., and Kinsey, W.H. (2004) Detection and measurement of membrane-bound protein tyrosine kinases in the zebrafish egg. In Germ Cell Protocols, Sperm and Oocyte Analysis. Schatten, H., Ed. Methods Mol. Biol. series. Columbia, MO: University of Missouri. 1:273-284
Kinsey, W.H., Wu, W., and Macgregor, E. (2003) Activation of Src-family PTK activity at fertilization: role of the SH2 domain. Developmental Biology. 264(1):255-262
Ken, C.F., Lin, C.T., Shaw, J.F., and Wu, J.L. (2003) Characterization of fish Cu/Zn-superoxide dismutase and its protection from oxidative stress. Marine biotechnology (New York, N.Y.). 5(2):167-173
Wu, W. and Kinsey, W.H. (2002) Role of PTPase(s) in regulating Fyn kinase at fertilization of the zebrafish egg. Developmental Biology. 247(2):286-94
Kinsey, W.H. and Wu, W.J. (2002) PTPase regulation of Fyn kinase at fertilization in the zebrafish egg. Biology of reproduction. (Suppl. 1) 66:M30
Wu, W. and Kinsey, W.H. (2000) Fertilization triggers activation of Fyn kinase in the zebrafish egg. The International journal of developmental biology. 44(8):837-841
Rongish, B.J. and Kinsey, W.H. (2000) Transient nuclear localization of Fyn kinase during development in zebrafish. The Anatomical record. 260(2):115-123