ZFIN ID: ZDB-LAB-001206-5
Sampath Lab
PI/Director: Sampath, Karuna
Contact Person: Sampath, Karuna
Email: K.Sampath@warwick.ac.uk
URL: http://www2.warwick.ac.uk/fac/med/research/biomedical/sampathlab
Address: Division of Biomedical Sciences Warwick Medical School The University of Warwick Coventry, CV4 7AJ United Kingdom
Country: United Kingdom
Phone: + 44 0 24 76573526
Fax:
Line Designation: ws


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show first 50 of 301 genomic features


STATEMENT OF RESEARCH INTERESTS
Maternal Control of Embryonic Development, RNA Localization, Translational control, Functional RNAs in the Genome; Maternal Nodal, Regulation of Nodal Signalling


LAB MEMBERS
Zaucker, Andreas Post-Doc Baliga, Keerthi Graduate Student Lambert, Finnlay Graduate Student
Leech, Rebecca Graduate Student Papafoti, Maria Graduate Student Polovinkins, Edgar Graduate Student
Bagley, Ian Fish Facility Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Nagorska, A., Zaucker, A., Lambert, F., Inman, A., Toral-Perez, S., Gorodkin, J., Wan, Y., Smutny, M., Sampath, K. (2023) Translational control of furina by an RNA regulon is important for left-right patterning, heart morphogenesis and cardiac valve function. Development (Cambridge, England). 150(23):
Zaucker, A., Mitchell, C.A., Coker, H.L.E., Sampath, K. (2021) Tools to Image Germplasm Dynamics During Early Zebrafish Development. Frontiers in cell and developmental biology. 9:712503
Vong, Y.H., Sivashanmugam, L., Leech, R., Zaucker, A., Jones, A., Sampath, K. (2021) The RNA-binding protein Igf2bp3 is critical for embryonic and germline development in zebrafish. PLoS Genetics. 17:e1009667
Pinto, C.S., Mishima, M., Sampath, K. (2020) Tools of the trade: studying actin in zebrafish. Histochemistry and cell biology. 154(5):481-493
Syed, J., Palani, S., Clarke, S.T., Asad, Z., Bottrill, A.R., Jones, A.M.E., Sampath, K., Balasubramanian, M.K. (2019) Expanding the Zebrafish Genetic Code through Site-Specific Introduction of Azido-lysine, Bicyclononyne-lysine, and Diazirine-lysine. International Journal of Molecular Sciences. 20(10):
Zaucker, A., Kumari, P., Sampath, K. (2019) Zebrafish embryogenesis - A framework to study regulatory RNA elements in development and disease. Developmental Biology. 457(2):172-180
Yi, X., Yu, J., Ma, C., Dong, G., Shi, W., Li, H., Li, L., Luo, L., Sampath, K., Ruan, H., Huang, H. (2019) The effector of Hippo signaling, Taz, is required for formation of the micropyle and fertilization in zebrafish. PLoS Genetics. 15:e1007408
Coverdale, J.P.C., Bridgewater, H.E., Song, J.I., Smith, N.A., Barry, N.P.E., Bagley, I., Sadler, P.J., Romero Canelon, I. (2018) In vivo selectivity and localization of reactive oxygen species (ROS) induction by osmium anticancer complexes that circumvent platinum-resistance. Journal of medicinal chemistry. 61(20):9246-9255
Weger, M., Diotel, N., Weger, B.D., Beil, T., Zaucker, A., Eachus, H.L., Oakes, J.A., do Rego, J.L., Storbeck, K.H., Gut, P., Straehle, U., Rastegar, S., Mueller, F., Krone, N. (2018) Expression and activity profiling of the steroidogenic enzymes of glucocorticoid biosynthesis and the fdx1 co-factors in zebrafish. Journal of neuroendocrinology. 30(4):e12586
Ng, X.W., Sampath, K., Wohland, T. (2018) Fluorescence Correlation and Cross-Correlation Spectroscopy in Zebrafish. Methods in molecular biology (Clifton, N.J.). 1863:67-105
Zaucker, A., Nagorska, A., Kumari, P., Hecker, N., Wang, Y., Huang, S., Cooper, L., Sivashanmugam, L., VijayKumar, S., Brosens, J., Gorodkin, J., Sampath, K. (2017) Translational co-regulation of a ligand and inhibitor by a conserved RNA element. Nucleic acids research. 46(1):104-119
Quach, H.N., Tao, S., Vrljicak, P., Joshi, A., Ruan, H., Sukumaran, R., Varshney, G.K., LaFave, M.C., Screen Team, T.D., Burgess, S.M., Winkler, C., Emelyanov, A., Parinov, S., Sampath, K. (2017) Expression Data for a Multifunctional Mutagenesis System for Analysis of Gene Function in Zebrafish. ZFIN Direct Data Submission.
Eachus, H., Zaucker, A., Oakes, J.A., Griffin, A., Weger, M., Güran, T., Taylor, A., Harris, A., Greenfield, A., Quanson, J.L., Storbeck, K.H., Cunliffe, V.T., Müller, F., Krone, N. (2017) Genetic disruption of 21-hydroxylase in zebrafish causes interrenal hyperplasia. Endocrinology. 158(12):4165-4173
Wang, Y., Wang, X., Wohland, T., Sampath, K. (2016) Extracellular interactions and ligand degradation shape the nodal morphogen gradient. eLIFE. 5:e13879
Vrljicak, P., Tao, S., Varshney, G.K., Quach, H.N., Joshi, A., LaFave, M.C., Burgess, S.M., Sampath, K. (2016) Genome-Wide Analysis of Transposon and Retroviral Insertions Reveals Preferential Integrations in Regions of DNA Flexibility. G3 (Bethesda). 6(4):805-17
Griffin, A., Parajes, S., Weger, M., Zaucker, A., Taylor, A.E., O'Neil, D.M., Müller, F., Krone, N. (2016) Ferredoxin 1b (Fdx1b) is the essential mitochondrial redox partner for cortisol biosynthesis in zebrafish. Endocrinology. 157(3):1122-34
Quach, H.N., Tao, S., Vrljicak, P., Joshi, A., Ruan, H., Sukumaran, R., Varshney, G.K., LaFave, M.C., Screen Team, T.D., Burgess, S.M., Winkler, C., Emelyanov, A., Parinov, S., Sampath, K. (2015) A Multifunctional Mutagenesis System for Analysis of Gene Function in Zebrafish. G3 (Bethesda). 5(6):1283-99
Zaucker, A., Bodur, T., Roest Crollius, H., Hadzhiev, Y., Gehrig, J., Loosli, F., Watson, C., Müller, F. (2014) Description of Embryonic Development of Spotted Green Pufferfish (Tetraodon nigroviridis). Zebrafish. 11(6):509-17
Young, T., Poobalan, Y., Tan, E.K., Tao, S., Ong, S., Wehner, P., Schwenty-Lara, J., Lim, C.Y., Sadasivam, A., Lovatt, M., Wang, S.T., Ali, Y., Borchers, A., Sampath, K., Dunn, N.R. (2014) The PDZ domain protein Mcc is a novel effector of non-canonical Wnt signaling during convergence and extension in zebrafish. Development (Cambridge, England). 141:3505-16
Kumari, P., Gilligan, P.C., Lim, S., Tran, L.D., Winkler, S., Philp, R., and Sampath, K. (2013) An essential role for maternal control of Nodal signaling. eLIFE. 2:e00683
Zaucker, A., Mercurio, S., Sternheim, N., Talbot, W.S., and Marlow, F.L. (2013) notch3 is essential for oligodendrocyte development and vascular integrity in zebrafish. Disease models & mechanisms. 6(5):1246-59
Lim, S., Wang, Y., Yu, X., Huang, Y., Featherstone, M.S., and Sampath, K. (2013) A simple strategy for heritable chromosomal deletions in zebrafish via the combinatorial action of targeting nucleases. Genome biology. 14(7):R69
Tran, L.D., Hino, H., Quach, H., Lim, S., Shindo, A., Mimori-Kiyosue, Y., Mione, M., Ueno, N., Winkler, C., Hibi, M., and Sampath, K. (2012) Dynamic microtubules at the vegetal cortex predict the embryonic axis in zebrafish. Development (Cambridge, England). 139(19):3644-3652
Lim, S., Kumari, P., Gilligan, P., Quach, H.N., Mathavan, S., and Sampath, K. (2012) Dorsal activity of maternal squint is mediated by a non-coding function of the RNA. Development (Cambridge, England). 139(16):2903-2915
Gilligan, P.C., Kumari, P., Lim, S., Cheong, A., Chang, A., and Sampath, K. (2011) Conservation defines functional motifs in the squint/nodal-related 1 RNA dorsal localization element. Nucleic acids research. 39(8):3340-9
Cullinane, A.R., Straatman-Iwanowska, A., Zaucker, A., Wakabayashi, Y., Bruce, C.K., Luo, G., Rahman, F., Gürakan, F., Utine, E., Ozkan, T.B., Denecke, J., Vukovic, J., Di Rocco, M., Mandel, H., Cangul, H., Matthews, R.P., Thomas, S.G., Rappoport, J.Z., Arias, I.M., Wolburg, H., Knisely, A.S., Kelly, D.A., Muller, F., Maher, E.R., and Gissen, P. (2010) Mutations in VIPAR cause an arthrogryposis, renal dysfunction and cholestasis syndrome phenotype with defects in epithelial polarization. Nature Genetics. 42(4):303-312
Csenki, Z., Zaucker, A., Kovacs, B., Hadzhiev, Y., Hegyi, R., Lefler, K.K., Muller, T., Kovacs, R., Urbanyi, B., Varadi, L., and Muller, F. (2010) Intraovarian transplantation of stage I-II follicles results in viable zebrafish embryos. The International journal of developmental biology. 54(4):585-589
Gehrig, J., Reischl, M., Kalmar, E., Ferg, M., Hadzhiev, Y., Zaucker, A., Song, C., Schindler, S., Liebel, U., and Muller, F. (2009) Automated high-throughput mapping of promoter-enhancer interactions in zebrafish embryos. Nature Methods. 6(12):911-916
Tao, S., Cai, Y., and Sampath, K. (2009) The Integrator subunits function in hematopoiesis by modulating Smad/BMP signaling. Development (Cambridge, England). 136(16):2757-2765
Tian, J., Andrée, B., Jones, C.M., and Sampath, K. (2008) The pro-domain of the zebrafish Nodal-related protein Cyclops regulates its signaling activities. Development (Cambridge, England). 135(15):2649-2658
Gore, A.V., Cheong, A., Gilligan, P.C., and Sampath, K. (2007) Gore et al. reply. Nature. 450(7167):E2-E4
Ramasamy, S., Wang, H., Quach, H.N., and Sampath, K. (2006) Zebrafish Staufen1 and Staufen2 are required for the survival and migration of primordial germ cells. Developmental Biology. 292(2):393-406
Gore, A.V., Maegawa, S., Cheong, A., Gilligan, P.C., Weinberg, E.S., and Sampath, K. (2005) The zebrafish dorsal axis is apparent at the four-cell stage. Nature. 438(7070):1030-1035
Tian, J., and Sampath, K. (2004) Formation and Functions of the Floor Plate. In Fish Development and Genetics - the Zebrafish and Medaka Models. Gong, Z. and Korh, V., Eds. Book series of "Molecular Aspects of Fish and Marine Biology". 239(9)
Tian, J., Yam, C., Balasundaram, G., Wang, H., Gore, A., and Sampath, K. (2003) A temperature-sensitive mutation in the nodal-related gene cyclops reveals that the floor plate is induced during gastrulation in zebrafish. Development (Cambridge, England). 130(14):3331-3342
Gore, A.V., and Sampath, K. (2002) Localization of transcripts of the zebrafish morphogen Squint is dependent on egg activation and the microtubule cytoskeleton. Mechanisms of Development. 112(1-2):153-156
Sampath, K., Rubinstein, A.L., Cheng, A.H.S., Liang, J.O., Fekany, K., Solnica-Krezel, L., Korzh, V., Halpern, M.E., and Wright, C.V.E. (1998) Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling. Nature. 395:185-189
Sampath, K. and Stuart, G.W. (1996) Developmental expression of class III and IV POU domain genes in the zebrafish. Biochemical and Biophysical Research Communications. 219:565-571
Sampath, K. (1995) Expression of POU domain genes in zebrafish development. Ph.D. Thesis.