Gene

tshr

ID

ZDB-GENE-110524-4

Name

thyroid stimulating hormone receptor

Symbol

tshr Nomenclature History

Previous Names

manet (1)
opallus (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Exhibits thyroid-stimulating hormone receptor activity. Involved in skeletal system development. Predicted to localize to integral component of plasma membrane. Used to study hyperthyroidism. Human ortholog(s) of this gene implicated in Graves' disease; cardiomyopathy; congenital nongoitrous hypothyroidism 1; and mitral valve prolapse. Is expressed in thyroid follicle and thyroid primordium. Orthologous to human TSHR (thyroid stimulating hormone receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tshr Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital nongoitrous hypothyroidism 1	Alliance	Hypothyroidism, congenital, nongoitrous, 1	275200
familial gestational hyperthyroidism	Alliance	Hyperthyroidism, familial gestational	603373
nonautoimmune hyperthyroidism	Alliance	Hyperthyroidism, nonautoimmune	609152
		Thyroid adenoma, hyperfunctioning, somatic
		Thyroid carcinoma with thyrotoxicosis, somatic

Associated With tshr Via Experimental Models

Human Disease	Fish	Conditions	Citations
hyperthyroidism	tshr^b1071/b1071	standard conditions	Hur et al., 2017

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR017452	GPCR, rhodopsin-like, 7TM
Family	IPR000276	G protein-coupled receptor, rhodopsin-like
Family	IPR002131	Glycoprotein hormone receptor family
Family	IPR002274	Thyrotropin receptor
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR026906	BspA-type LRR region

Domain Details Per Protein

Protein	Length	BspA-type LRR region	Glycoprotein hormone receptor family	GPCR, rhodopsin-like, 7TM	G protein-coupled receptor, rhodopsin-like	Leucine-rich repeat	Leucine-rich repeat domain superfamily	Thyrotropin receptor
UniProtKB:C0SKM5 InterPro	757

Transcripts

Genome Browsers

NCBI

No data available

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations