Gene

itgav

ID

ZDB-GENE-060616-382

Name

integrin, alpha V

Symbol

itgav Nomenclature History

Previous Names

zgc:136222 (1)

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Involved in several processes, including Kupffer's vesicle development; axis elongation involved in somitogenesis; and cell migration involved in gastrulation. Localizes to integrin complex. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and acute myeloid leukemia. Is expressed in several structures, including axis; diencephalon; head; pleuroperitoneal region; and post-vent vasculature. Orthologous to human ITGAV (integrin subunit alpha V).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With itgav Human Ortholog

No data available

Associated With itgav Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018184	Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Domain	IPR013649	Integrin alpha, first immunoglubulin-like domain
Domain	IPR048285	Integrin alpha, second immunoglobulin-like domain
Domain	IPR048286	Integrin alpha, third immunoglobulin-like domain
Family	IPR000413	Integrin alpha chain
Homologous_superfamily	IPR028994	Integrin alpha, N-terminal
Homologous_superfamily	IPR032695	Integrin domain superfamily
Repeat	IPR013517	FG-GAP repeat
Repeat	IPR013519	Integrin alpha beta-propellor

Domain Details Per Protein

Protein	Length	FG-GAP repeat	Integrin alpha beta-propellor	Integrin alpha chain	Integrin alpha chain, C-terminal cytoplasmic region, conserved site	Integrin alpha, first immunoglubulin-like domain	Integrin alpha, N-terminal	Integrin alpha, second immunoglobulin-like domain	Integrin alpha, third immunoglobulin-like domain	Integrin domain superfamily
UniProtKB:Q3LTM3 InterPro	1045

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	itgav-201 (1) Ensembl	Havana	4328 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	itgav-002 (1) Ensembl	Havana	1338 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations