Gene

xrcc6

ID

ZDB-GENE-030131-6420

Name

X-ray repair complementing defective repair in Chinese hamster cells 6

Symbol

xrcc6 Nomenclature History

Previous Names

g22p1
Ku autoantigen
Ku70
wu:fi87b06
zgc:64131

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to contribute to double-stranded DNA binding activity. Involved in response to ionizing radiation. Predicted to localize to Ku70:Ku80 complex and nuclear chromosome, telomeric region. Is expressed in head; nervous system; neural keel; post-vent region; and presumptive neural retina. Orthologous to human XRCC6 (X-ray repair cross complementing 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:64131 (7 images)
IMAGE:7139458 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Feitsma et al., 2008
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With xrcc6 Human Ortholog

No data available

Associated With xrcc6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002035	von Willebrand factor, type A
Domain	IPR003034	SAP domain
Domain	IPR005160	Ku70/Ku80 C-terminal arm
Domain	IPR005161	Ku70/Ku80, N-terminal alpha/beta
Domain	IPR006164	Ku70/Ku80 beta-barrel domain
Domain	IPR047087	Ku70, core domain
Family	IPR006165	Ku70
Homologous_superfamily	IPR016194	SPOC-like, C-terminal domain superfamily
Homologous_superfamily	IPR027388	Ku70, bridge and pillars domain superfamily
Homologous_superfamily	IPR036361	SAP domain superfamily
Homologous_superfamily	IPR036465	von Willebrand factor A-like domain superfamily