Gene

ptch2

ID

ZDB-GENE-980526-44

Name

patched 2

Symbol

ptch2 Nomenclature History

Previous Names

ptc-1
ptc1
blowout (1)
blw (1)
etID309849.2 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have hedgehog family protein binding activity; hedgehog receptor activity; and smoothened binding activity. Involved in several processes, including cardioblast differentiation; negative regulation of smoothened signaling pathway; and retinal ganglion cell axon guidance. Predicted to localize to plasma membrane. Used to study coloboma. Human ortholog(s) of this gene implicated in basal cell carcinoma; medulloblastoma; and nevoid basal cell carcinoma syndrome. Is expressed in several structures, including central nervous system; digestive system; head; mesoderm; and musculature system. Orthologous to human PTCH2 (patched 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

206 figures from 146 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu467 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 29 figures from 10 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ptch2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
medulloblastoma	Alliance	Medulloblastoma, somatic	155255
		Basal cell carcinoma, somatic	605462

Associated With ptch2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
coloboma	ptch2^{tc294z/tc294z}	standard conditions	Gordon et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000731	Sterol-sensing domain
Family	IPR003392	Protein patched/dispatched
Family	IPR004766	Transmembrane receptor, patched

Domain Details Per Protein

Protein	Length	Protein patched/dispatched	Sterol-sensing domain	Transmembrane receptor, patched
UniProtKB:Q98864 InterPro	1220
UniProtKB:F1Q8S0 InterPro	1442

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ptch2-202 (1) Ensembl	Havana	4420 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

SignaFish

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-ptch2		ptch2		Goat	IHC	Everest Biotech	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations