Gene
stat3
- ID
- ZDB-GENE-980526-68
- Name
- signal transducer and activator of transcription 3 (acute-phase response factor)
- Symbol
- stat3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; cardiac muscle tissue regeneration; and generation of neurons. Predicted to localize to cytosol and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; carcinoma (multiple); hyper IgE recurrent infection syndrome 1; inflammatory bowel disease (multiple); and reproductive organ cancer (multiple). Is expressed in blastomere; epidermal superficial stratum; head; immature eye; and nervous system. Orthologous to human STAT3 (signal transducer and activator of transcription 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 60 figures from 36 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55197 (9 images)
- eu734 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hyper IgE recurrent infection syndrome 1 | Alliance | Hyper-IgE syndrome 1, autosomal dominant, with recurrent infections | 147060 |
| Autoimmune disease, multisystem, infantile-onset, 1 | 615952 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000980 | SH2 domain |
| Domain | IPR013799 | STAT transcription factor, protein interaction |
| Domain | IPR013800 | STAT transcription factor, all-alpha domain |
| Domain | IPR013801 | STAT transcription factor, DNA-binding |
| Domain | IPR035855 | STAT3, SH2 domain |
| Domain | IPR048988 | Signal transducer and activator of transcription, linker domain |
| Family | IPR001217 | Transcription factor STAT |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR012345 | STAT transcription factor, DNA-binding, N-terminal |
| Homologous_superfamily | IPR015988 | STAT transcription factor, coiled coil |
| Homologous_superfamily | IPR036535 | STAT transcription factor, N-terminal domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | p53-like transcription factor, DNA-binding domain superfamily | SH2 domain | SH2 domain superfamily | Signal transducer and activator of transcription, linker domain | STAT3, SH2 domain | STAT transcription factor, all-alpha domain | STAT transcription factor, coiled coil | STAT transcription factor, DNA-binding | STAT transcription factor, DNA-binding, N-terminal | STAT transcription factor, N-terminal domain superfamily | STAT transcription factor, protein interaction | Transcription factor STAT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BB24
|
821 | ||||||||||||
|
UniProtKB:A0A8M2BAX1
|
801 | ||||||||||||
|
UniProtKB:A0A8M2BBA1
|
753 | ||||||||||||
|
UniProtKB:O93599
|
806 | ||||||||||||
|
UniProtKB:A0A0R4IGF2
|
738 | ||||||||||||
|
UniProtKB:Q6NV46
|
786 |
Interactions and Pathways
Plasmids
No data available