ZFIN Human Disease: Werner syndrome

OBO ID: DOID:5688

Term Name:	Werner syndrome		Search Ontology:
Synonyms:	adult premature ageing syndrome adult progeria Werner's syndrome WS
Definition:	A progeroid syndrome characterized by premature aging and age-related phenotypes such as atherosclerosis, arteriosclerosis, cataracts, osteoporosis, soft tissue calcification, premature thinning, graying, and loss of hair, as well as a high incidence of some types of cancers and that has_material_basis_in mutations in the WRN gene, on chromosome 8. (3)
References:	GARD:7885 MESH:D014898 NCI:C3447 OMIM:277700 ORDO:902 SNOMEDCT_US_2023_03_01:51626007 UMLS_CUI:C0043119
Ontology:	Human Disease ( DOID:5688 )

Relationships

is a type of:	autosomal recessive disease progeroid syndrome autosomal recessive disease progeroid syndrome Show first 5 Terms

OTHER Werner syndrome PAGES

Alliance (1)

GENES INVOLVED

Human Gene	Zebrafish Ortholog	OMIM Term	OMIM Phenotype ID
WRN	wrn	Werner syndrome	277700

ZEBRAFISH MODELS

Fish	Conditions	Citations
shox^{sa41471/sa41471}	standard conditions	Tian et al., 2022
wrn^{sa34829/sa34829}	standard conditions	Tian et al., 2022

PHENOTYPE No data available

CITATIONS (1)