ZFIN Human Disease: visceral heterotaxy

OBO ID: DOID:0050545

Term Name:	visceral heterotaxy		Search Ontology:
Synonyms:	heterotaxia situs ambiguus
Definition:	A physical disorder characterized by the abnormal distribution of the major visceral organs within the chest and abdomen. http://en.wikipedia.org/wiki/Situs_ambiguus
References:	GARD:10875 OMIM:306955 OMIM:605376 OMIM:606325 OMIM:613751 OMIM:614779 OMIM:PS306955 ORDO:450
Ontology:	Human Disease ( DOID:0050545 )

Relationships

is a type of:	physical disorder physical disorder Show first 5 Terms
has subtype:	right atrial isomerism situs inversus right atrial isomerism situs inversus Show first 5 Terms

OTHER visceral heterotaxy PAGES

Alliance (1)

GENES INVOLVED

Human Gene	Zebrafish Ortholog	OMIM Term	OMIM Phenotype ID
ACVR2B	acvr2bb acvr2ba	Heterotaxy, visceral, 4, autosomal	613751
CFAP53	cfap53	Heterotaxy, visceral, 6, autosomal recessive	614779
ZIC3	zic3	Congenital heart defects, nonsyndromic, 1, X-linked	306955
		Heterotaxy, visceral, 1, X-linked	306955
CFC1		Heterotaxy, visceral, 2, autosomal

ZEBRAFISH MODELS

Fish	Conditions	Citations
WT	chemical treatment: 3-(2,4-dichlorophenyl)-7-hydroxy-4H-chromen-4-one	Burkhalter et al., 2019
	chemical treatment: rotenone	Burkhalter et al., 2019
cfap53^{hu10478/hu10478}	standard conditions	Noël et al., 2016
AB + MO1-zic3	standard conditions	Cast et al., 2012
WT + MO1-cox5aa	standard conditions	Burkhalter et al., 2019
WT + MO1-mtrr	standard conditions	Burkhalter et al., 2019
WT + MO1-osbpl1a	standard conditions	Burkhalter et al., 2019
WT + MO1-phka2	standard conditions	Burkhalter et al., 2019
WT + MO4-tafazzin	standard conditions	Burkhalter et al., 2019
WT + TALEN1-cc2d1a	standard conditions	Ma et al., 2020
cc2d1a^phk1/+	standard conditions	Ma et al., 2020

PHENOTYPE No data available

CITATIONS (12)