ZFIN Cell Ontology: T follicular helper cell

OBO ID: CL:0002038

Term Name:	T follicular helper cell		Search Ontology:
Synonyms:	follicular B helper T cell follicular helper T cell follicular helper T-cell follicular T cell follicular T-cell follicular T-helper cell T(FH) Tfh
Definition:	A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that expresses is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production. (3)
References:
Ontology:	Cell Ontology

Relationships

develops from:	activated CD4-positive, alpha-beta T cell activated CD4-positive, alpha-beta T cell Show first 5 Terms
is a type of:	CD4-positive helper T cell CD4-positive helper T cell Show first 5 Terms
capable_of:	positive regulation of isotype switching positive regulation of isotype switching Show first 5 Terms
has_part:	B-cell lymphoma 6 protein B-cell lymphoma 6 protein Show first 5 Terms
has_plasma_membrane_part:	C-X-C chemokine receptor type 5 inducible T-cell costimulator programmed cell death protein 1 C-X-C chemokine receptor type 5 inducible T-cell costimulator programmed cell death protein 1 Show first 5 Terms
lacks_plasma_membrane_part:	C-C chemokine receptor type 7 C-C chemokine receptor type 7 Show first 5 Terms

PHENOTYPE No data available