OBO ID: CHEBI:91376

Term Name:	ZM447439		Search Ontology:
Synonyms:	N-(4-((6-methoxy-7-(3-(4-morpholinyl)propoxy)-4-quinazolinyl)amino)phenyl)benzamide N-[4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinazolin-4-yl}amino)phenyl]benzamide N-[4-[[6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-yl]amino]phenyl]benzamide ZM 447439 ZM-447439 ZM447439
Definition:	A member of the class of quinazolines that is quinazoline which is substituted at positions 4, 6 and 7 by a (4-benzamidophenyl)nitrilo group, methoxy group and a 3-(morpholin-4-yl)propoxy group, respectively. It is an ATP-competitive inhibitor of Aurora A and Aurora B kinases with IC50 of 110 nM and 130 nM, respectively.
References:	CAS:331771-20-1 LINCS:LSM-1096 PDB:2VRX PDBeChem:447 PMID:12719470 PMID:15616188 PMID:18367484 PMID:18418083 PMID:18559266 PMID:19298889 PMID:19686703 PMID:19923785 PMID:21099354 PMID:21159048 PMID:21775627 PMID:23613471 PMID:24152827 PMID:24680981 PMID:24748653 PMID:29147452 Wikipedia:ZM447439
Ontology:	ChEBI  ( EBI )