OBO ID: CHEBI:77823

Term Name:	tilidine		Search Ontology:
Synonyms:	ethyl trans-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate rac-ethyl (1R,2S)-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate rac-ethyl (1S,2R)-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate tilidina tilidine tilidinum
Definition:	A racemate that is an equimolar mixture of the two trans diastereoisomers of ethyl 2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate, namely dextilidine and ent-dextilidine. It is used (commonly as the hydrochloride hemihydrate) as an opioid analgesic for the management of moderate to severe pain. A prodrug, it is metabolised in the body to nortilidine, which is responsible for the analgesic activity; virtually all of the opioid activity resides in the (1S,2R) isomer.
References:	CAS:51931-66-9 KEGG:D08597 PMID:11144998 PMID:21140136 PMID:212687 PMID:22381043 PMID:23844964 PMID:2610722 PMID:3803198 PMID:6852098 PMID:720208 Patent:GB1120186 Patent:US3557127 Reaxys:2813935 Wikipedia:Tilidine
Ontology:	ChEBI  ( EBI )