OBO ID: CHEBI:64203

Term Name:	methiothepin		Search Ontology:
Synonyms:	(+-)-1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiperazine (+-)-10-(4-Methylpiperazinyl)-8-(methylthio)-10,11-dihydrodibenzo(b,f)thiepin (+-)-8-Methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin 1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiperazine 1-methyl-4-[8-(methylsulfanyl)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazine 1-methyl-4-[8-(methylthio)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazine Methiothepine metitepina metitepine metitepinum
Definition:	A dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).
References:	CAS:20229-30-5 HMDB:HMDB0254534 LINCS:LSM-4320 PMID:18033297 PMID:18996971 PMID:19837141 PMID:19995401 PMID:20171242 PMID:20233210 PMID:20331882 PMID:20547148 PMID:21062995 PMID:21403818 PMID:21514998 PMID:21964383 Patent:NL6608618 Patent:US3379729 Patent:US4444778 Patent:US6331536 Reaxys:626221 Wikipedia:Metitepine
Ontology:	ChEBI  ( EBI )