OBO ID: CHEBI:4392

Term Name:	demeclocycline		Search Ontology:
Synonyms:	(4S,4aS,5aS,6S,12aS)-7-chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide 6-demethyl-7-chlorotetracycline 7-chloro-6-demethyltetracycline [4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha)]-7-chloro-4-(dimethylamino)1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide demeclociclina Demeclocycline demeclocyclinum demethylchlortetracycline DMCT DMCTC
Definition:	Tetracycline which lacks the methyl substituent at position 7 and in which the hydrogen para- to the phenolic hydroxy group is substituted by chlorine. Like tetracycline, it is an antibiotic, but being excreted more slowly, effective blood levels are maintained for longer. It is used (mainly as the hydrochloride) for the treatment of Lyme disease, acne and bronchitis, as well as for hyponatraemia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) where fluid restriction alone has been ineffective.
References:	Beilstein:2230579 CAS:127-33-3 Chemspider:10482117 DrugBank:DB00618 Drug_Central:802 KEGG:D00290 KEGG:D03680 PMID:24134630 Patent:FR1344645 Patent:US2878289 Patent:US3012946 Patent:US3019172 Patent:US3050446 Patent:US3154476 Wikipedia:Demeclocycline
Ontology:	ChEBI  ( EBI )