OBO ID: CHEBI:167900
Term Name: PJ34 Search Ontology:
Synonyms:
  • 2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide
  • 2-(dimethylaminoacetylamino)-5,6-dihydrophenanthridine-6-one
  • N(2),N(2)-dimethyl-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)glycinamide
  • N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)acetamide
  • N-(5,6-dihydro-6-oxophenanthridine-2-yl)-2-(dimethylamino)acetamide
  • PJ 34
  • PJ-34
Definition: A member of the class of phenanthridines that is 5,6-dihydrophenanthridine substituted at positions 2 and 6 by (N,N-dimethylglycyl)amino and oxo groups, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 110 nM and 86 nM, respectively) and exhibits anti-cancer, cardioprotective and neuroprotective properties.
References:
Ontology: ChEBI  ( EBI )
Relationships
is a type of:
has_role:
inverse is_conjugate_acid_of:
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PHENOTYPE No data available

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