OBO ID: CHEBI:145365

Term Name:	crenolanib		Search Ontology:
Synonyms:	1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo-[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine 1-(2-{5-[(3-methyloxetan-3-yl)methoxy]-1H-1,3-benzodiazol-1-yl}quinolin-8-yl)piperidin-4-amine 1-(2-{5-[(3-methyloxetan-3-yl)methoxy]-1H-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine 1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1-benzimidazolyl]-8-quinolyl]-4-piperidinamine 1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine ARO 002 ARO-002 CP 868596 CP-868,596 CP-868596 CP868569 crenolanib crenolanibum
Definition:	A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a 8-(4-aminopiperidin-1-yl)quinolin-2-yl group at position 1 and by a (3-methyloxetan-3-yl)methoxy group at position 5. It is an inhibitor of type III tyrosine kinases, PDGFRalpha/beta and FLT3 (IC50 of 11, 3.2, and 4 nM). Currently under clinical development for the treatment of acute myeloid leukemia.
References:	CAS:670220-88-9 DrugBank:DB11832 KEGG:D10102 PDBeChem:6T2 PMID:19738123 PMID:20959830 PMID:22745105 PMID:23644495 PMID:24046014 PMID:24132921 PMID:24227820 PMID:24263951 PMID:24623852 PMID:25328409 PMID:25597754 PMID:28433542 PMID:28943249 PMID:29137311 PMID:29191878 PMID:29312564 PMID:29472720 PMID:30651561 PMID:30942519 PMID:31235865 PMID:31309543 Wikipedia:Crenolanib
Ontology:	ChEBI  ( EBI )