OBO ID: CHEBI:138650

Term Name:	CBL0137		Search Ontology:
Synonyms:	1,1'-{9-[2-(isopropylamino)ethyl]-9H-carbazole-3,6-diyl}diethanone 1,1'-{9-[2-(propan-2-ylamino)ethyl]-9H-carbazole-3,6-diyl}diethanone 3,6-diacetyl-9-(2-isopropylethyl)-9H-carbazole CBL-0137 free base CBLC137 Curaxin 137 Curaxin-137
Definition:	A member of the class of carbazoles that is 9H-carbazole which is substituted by acetyl groups at positions 3 and 6, and by a 2-isopropylethyl group on the nitrogen atom (position 9). It is a modulator of histone chaperone FACT (FAcilitates Chromatin Transcription) - interaction of CBL0137 with the FACT complex results in simultaneous NF-kappa beta suppression, Heat Shock Transcription Factor 1 (HSF1) suppression and p53 activation - and shows antitumour effects in animal models of various cancers.
References:	CAS:1197996-80-7 PMCID:PMC4903394 PMID:25402820 PMID:26537256 PMID:26921329 PMID:27370399 PMID:27650817 PMID:27680682 PMID:28480210 Patent:WO2013148864 Reaxys:24576552
Ontology:	ChEBI  ( EBI )