OBO ID: CHEBI:134547 |
Term Name: | TOP-53 | Search Ontology: | |
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Definition: | A furonaphthodioxole that is 4'-demethyldeoxypodophyllotoxin which is substituted at position 4 of the C-ring by a 2-{[2-(dimethylamino)ethyl](methyl)amino}ethyl group. While structurally related to etoposide, TOP-53 is significantly more toxic to non-small cell lung cancer cells, more active at generating chromosomal breaks, and displays improved cellular uptake and pharmacokinetics in animal lung tissues. | ||
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Ontology: | ChEBI ( EBI ) |
PHENOTYPE
No data available