Term Name: | negative regulation of pyruvate decarboxylation to acetyl-CoA |
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Synonyms: | negative regulation of acetyl-CoA biosynthetic process from pyruvate |
Definition: | Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. In most organisms, this pathway links glycolysis to the TCA cycle, by a series of three reactions carried out by a multisubunit complex called the 'pyruvate dehydrogenase complex', even though pyruvate dehydrogenase activity describes only one of those reactions. |
Ontology: | GO: Biological Process [GO:0160218] QuickGO AmiGO |