| Synonyms: |
3-oxo-5beta-steroid:NADP+ delta4-oxidoreductase activity,
3-oxo-Delta(4)-steroid 5-beta-reductase activity,
3-oxo-Delta4-steroid 5beta-reductase activity,
4,5beta-dihydrocortisone:NADP+ delta4-oxidoreductase activity,
5-beta-reductase activity,
5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase activity,
5beta-reductase activity,
androstenedione 5-beta-reductase activity,
androstenedione 5beta-reductase activity,
cholestenone 5-beta-reductase activity,
cholestenone 5b-reductase activity,
cholestenone 5beta-reductase activity,
cortisone 5-beta-reductase activity,
cortisone 5beta-reductase activity,
cortisone b-reductase activity,
cortisone beta-reductase activity,
cortisone delta(4)-5-beta-reductase activity,
cortisone delta4-5beta-reductase activity,
Delta(4)-3-ketosteroid 5-beta-reductase activity,
Delta(4)-5-beta-reductase activity,
Delta(4)-hydrogenase activity,
Delta4-3-ketosteroid 5beta-reductase activity,
Delta4-3-oxosteroid 5-beta-reductase activity,
Delta4-5beta-reductase activity,
Delta4-hydrogenase activity,
steroid 5-beta-reductase activity,
steroid 5beta-reductase activity,
testosterone 5-beta-reductase activity,
testosterone 5beta-reductase activity
|
| Definition: |
Catalysis of the reaction: a 3-oxo-5beta-steroid + NADP+ = a 3-oxo-Delta(4)-steroid + H+ + NADPH. The enzyme from human efficiently catalyzes the reduction of progesterone, androstenedione, 17alpha-hydroxyprogesterone and testosterone to 5beta-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent. The bile acid intermediates 7alpha,12alpha-dihydroxy-4-cholesten-3- one and 7alpha-hydroxy-4-cholesten-3-one can also act as substrates. |