Term Name: | protein targeting to ER |
---|---|
Synonyms: | protein targeting to endoplasmic reticulum, protein-endoplasmic reticulum targeting, protein-ER targeting |
Definition: | The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane. |
Ontology: | GO: Biological Process [GO:0045047] QuickGO AmiGO |