Term Name: ATF6-mediated unfolded protein response
Synonyms: activating transcription factor 6 signaling in unfolded protein response, ATF6 branch of UPR, ATF6 signal transduction pathway, ATF6 signaling in response to endoplasmic reticulum stress, ATF6-alpha UPR branch, ATF6-beta UPR branch, endoplasmic reticulum unfolded protein response; ATF6 signaling, UPR signaling by ATF6 stress sensor
Definition: The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity.
Ontology: GO: Biological Process [GO:0036500]    QuickGO    AmiGO

Relationships
is a type of: endoplasmic reticulum unfolded protein response ER-nucleus signaling pathway
negatively regulated by: negative regulation of ATF6-mediated unfolded protein response
positively regulated by: positive regulation of ATF6-mediated unfolded protein response
regulated by: regulation of ATF6-mediated unfolded protein response