Term Name:	Notch receptor processing, ligand-dependent
Synonyms:	Notch S2 cleavage, Notch S3 cleavage
Definition:	The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD).
Ontology:	GO: Biological Process [GO:0035333]    QuickGO    AmiGO