Term Name: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Synonyms: deoxyribonucleate topoisomerase, deoxyribonucleic topoisomerase activity, DNA gyrase activity, DNA topoisomerase (ATP-hydrolysing), DNA topoisomerase II, DNA topoisomerase II activity, DNA topoisomerase IV activity, DNA topoisomerase type II activity, DNA-gyrase activity, topoisomerase, topoisomerase II, type II DNA topoisomerase activity
Definition: Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.
Ontology: GO: Molecular Function [GO:0003918]    QuickGO    AmiGO

Relationships
is a type of: ATP-dependent activity, acting on DNA DNA topoisomerase activity
has subtype: DNA negative supercoiling activity
negatively regulated by: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
positively regulated by: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
regulated by: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity