Term Name: MAPK cascade
Synonyms: ERK/MAPK cascade, MAP kinase cascade, MAP kinase kinase kinase cascade, MAPK signal transduction, MAPK signaling, MAPK signalling, MAPKKK cascade, MAPKKK cascade during sporulation, mitogen-activated protein kinase cascade
Definition: An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
Ontology: GO: Biological Process [GO:0000165]    QuickGO    AmiGO

Relationships
has parts: MAP kinase activity MAP kinase kinase activity MAP kinase kinase kinase activity MAP kinase kinase kinase kinase activity MAP-kinase scaffold activity
is a type of: intracellular signaling cassette
has subtype: ERK1 and ERK2 cascade ERK5 cascade JNK cascade p38MAPK cascade pheromone response MAPK cascade stress-activated MAPK cascade
negatively regulated by: negative regulation of MAPK cascade
positively regulated by: positive regulation of MAPK cascade positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
regulated by: regulation of MAPK cascade