Term Name:	Reis-Bucklers corneal dystrophy
Synonyms:	anterior limiting membrane dystrophy type I, corneal dystrophy of Bowman layer type I, geographic corneal dystrophy, granular corneal dystrophy type III, RBCD
Definition:	An epithelial-stromal TGFBI dystrophy that is characterized by recurrent erosions and irregular geographic opacification located_in the cornea, proteinaceous deposits in the anterior stroma and subepithelium, and progressive early vision loss, and has_material_basis_in heterozygous mutation of transforming growth factor beta-induced gene located in chromosome 5q31.1, which encodes keratoepithelin. Abnormalities lead to increased protein deposition and disruption especially of Bowman's membrane of the cornea.
Ontology:	Human Disease [DOID:0060453]   ( DOID:0060453 )