Term Name: | SU4312 |
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Synonyms: | 3-(4-dimethylamino-benzylidenyl)-2-indolinone, 3-[4-(dimethylamino)benzylidene]-1,3-dihydro-2H-indol-2-one, 3-[[4-(dimethylamino)phenyl]methylidene]-1H-indol-2-one, DMBI, SU 4312, SU-4312 |
Definition: | A member of the class of oxindoles that is 3-methyleneoxindole in which one of the hydrogens of the methylene group has been replaced by a p-(dimethylamino)phenyl group. SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity. |
Ontology: | ChEBI [CHEBI:92369] ( EBI ) |