Term Name: abexinostat
Synonyms: 3-[(dimethylamino)methyl]-N-[2-[4-(hydroxycarbamoyl)phenoxy]ethyl]-1-benzofuran-2-carboxamide, 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)-oxomethyl]phenoxy]ethyl]-2-benzofurancarboxamide, 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamide, 3-[(dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofuran-2-carboxamide, abexinostat, abexinostatum, CRA 024781, CRA 24781, CRA-024781, PCI 24781, PCI-24781, PZP-115891, PZP115891, S-78454, S78454
Definition: A 1-benzofuran substituted by {2-[4-(hydroxycarbamoyl)phenoxy]ethyl}aminocarbonyl and (dimethylamino)methyl groups at positions 2 and 3, respectively. It is a potent pan-HDAC inhibitor whose major target is HDAC1 (Ki = 7 nM).
Ontology: ChEBI [CHEBI:92223]  ( EBI )

Relationships
is a type of: 1-benzofurans aromatic ether hydroxamic acid secondary carboxamide tertiary amino compound
has_role: antineoplastic agent apoptosis inducer autophagy inducer EC 3.5.1.98 (histone deacetylase) inhibitor radiosensitizing agent