Term Name: GW843682X
Synonyms: 5-(5,6-dimethoxy-1-benzimidazolyl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamide, 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)benzyl]oxy}thiophene-2-carboxamide, 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)phenyl]methoxy}thiophene-2-carboxamide, GW 843682X, GW-843682X, GW843682
Definition: A member of the class of benzimidazoles that is 1H-benzimidazole substituted by 5-carbamoyl-4-{[2-(trifluoromethyl)phenyl]methoxy}thiophen-2-yl, methoxy, and methoxy groups at positions 1, 5, and 6, respectively. It is a potent inhibitor of PLK1 and PLK3 (IC50 = 2.2 and 9.1 nM respectively).
Ontology: ChEBI [CHEBI:91334]  ( EBI )

Relationships
is a type of: (trifluoromethyl)benzenes aromatic ether benzimidazoles primary carboxamide thiophenes
has_role: antineoplastic agent apoptosis inducer EC 2.7.11.21 (polo kinase) inhibitor