Term Name:	rolapitant
Synonyms:	(5S,8S)-8-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-8-phenyl-1,7-diazaspiro[4.5]decan-2-one, rolapitant, SCH 619734, SCH-619734
Definition:	An azaspiro compound that is 1,7-diazaspiro[4.5]decan-2-one carrying additional phenyl and 1-{[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl substituents at position 8. Used (in the form of the hydrochloride hydrate) for the prevention of delayed nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy.
Ontology:	ChEBI [CHEBI:90908] ( EBI )

Relationships

is a type of:	azaspiro compound ether organofluorine compound piperidines pyrrolidin-2-ones
has_role:	antiemetic neurokinin-1 receptor antagonist
inverse is_conjugate_acid_of:	rolapitant(1+)
is_conjugate_base_of:	rolapitant(1+)