Term Name: crizotinib
Synonyms: (R)-crizotinib, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine, crizotinib, crizotinibum, PF 2341066, PF-2341066
Definition: A 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that has R configuration at the chiral centre. The active enantiomer, it acts as a kinase inhibitor and is used for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)
Ontology: ChEBI [CHEBI:64310]  ( EBI )

Relationships
is a type of: 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine
has_role: antineoplastic agent biomarker EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
inverse has_part: rac-crizotinib
inverse is_enantiomer_of: ent-crizotinib
is_enantiomer_of: ent-crizotinib