Term Name: 7-chlorokynurenic acid
Synonyms: 7-chloro-4-hydroxy-2-carboxyquinoline, 7-chloro-4-hydroxyquinoline-2-carboxylic acid, 7-CKA, 7-Cl-KYNA
Definition: A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the NMDA receptor. It also prevents neurodegeneration produced by quinolinic acid.
Ontology: ChEBI [CHEBI:63965]  ( EBI )

Relationships
is a type of: organochlorine compound quinolinemonocarboxylic acid
has_role: neuroprotective agent NMDA receptor antagonist