Term Name: 3-(5-fluorouracil-1-yl)-L-alanine
Synonyms: (2S)-2-amino-3-(5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acid, (S)-(-)-5-fluorowillardiine, (S)-alpha-Amino-5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimmidinepropanoic acid, (S)-F-Willardiine, 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, 3-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, 5-Fluorowillardiine
Definition: An alanine derivative that is L-alanine bearing a 5-fluorouracil-1-yl substituent at position 3. A more potent and selective AMPA receptor agonist (at hGluR1 and hGluR2) than AMPA itself (Ki = 14.7, 25.1, and 1820 nM for hGluR1, hGluR2 and hGluR5 respectively).
Ontology: ChEBI [CHEBI:42549]  ( EBI )

Relationships
is a type of: L-alanine derivative non-proteinogenic L-alpha-amino acid organofluorine compound
has_functional_parent: uracil
has_role: AMPA receptor agonist