Term Name: dWIZ-2
Synonyms: 3-(5-{[(2R)-1-ethylpiperidin-2-yl]methoxy}-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione, 3-[6-[[(2R)-1-ethylpiperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione, dWIZ 2, dWIZ2, HbF inducer 2
Definition: A member of the class of isoindoles that is 2,3-dihydro-1H-isoindol-1-one substituted by 2,6-dioxopiperidin-3-yl and [(2R)-1-ethylpiperidin-2-yl]methoxy groups at positions 2 and 5, respectively. It is a molecular glue degrader of the WIZ transcription factor that induces fetal hemoglobin in eythroblasts, and a potential therapeutic agent for the treatment of Sickle cell disease.
Ontology: ChEBI [CHEBI:233640]  ( EBI )

Relationships
is a type of: aromatic ether isoindoles piperidines piperidones tertiary amino compound