Term Name: zipalertinib
Synonyms: (S)-N-(4-amino-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido(5,4-b)indolizin-8-yl)acrylamide, CLN 081, CLN-081, CLN081, N-[(8S)-4-amino-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido[5,4-b]indolizin-8-yl]prop-2-enamide, TAS 6417, TAS-6417, TAS6417, TPC 064, TPC-064, TPC064, zipalertinib, zipalertinibum
Definition: A member of the class of acrylamides that is (8S)-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido[5,4-b]indolizine-4,8-diamine in which the amino group at position 8S is substituted by an acryloyl group. It a covalent epidermal growth factor receptor inhibitor that targets exon 20 insertion mutations.
Ontology: ChEBI [CHEBI:233402]  ( EBI )

Relationships
is a type of: acrylamides aromatic amine organic heterotricyclic compound primary amino compound quinolines secondary carboxamide
has_role: antineoplastic agent apoptosis inducer epidermal growth factor receptor antagonist