Term Name: | zipalertinib |
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Synonyms: | (S)-N-(4-amino-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido(5,4-b)indolizin-8-yl)acrylamide, CLN 081, CLN-081, CLN081, N-[(8S)-4-amino-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido[5,4-b]indolizin-8-yl]prop-2-enamide, TAS 6417, TAS-6417, TAS6417, TPC 064, TPC-064, TPC064, zipalertinib, zipalertinibum |
Definition: | A member of the class of acrylamides that is (8S)-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido[5,4-b]indolizine-4,8-diamine in which the amino group at position 8S is substituted by an acryloyl group. It a covalent epidermal growth factor receptor inhibitor that targets exon 20 insertion mutations. |
Ontology: | ChEBI [CHEBI:233402] ( EBI ) |