Term Name: SB-743921
Synonyms: GSK 743921, GSK-743921, GSK-921, GSK743921, N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxo-4H-chromen-2-yl)-2-methylpropyl]-4-methylbenzamide, N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxochromen-2-yl)-2-methylpropyl]-4-methylbenzamide, SB 743921, SB-743921 free base, SB-921, SB743921
Definition: A chromone that is 4H-chromen-4-one substituted by (1R)-1-[(3-aminopropyl)(4-methylbenzoyl)amino]-2-methylpropyl, benzyl, and chloro groups at positions 2, 3, and 7, respectively. It is a potent inhibitor of kinesin spindle protein (Ki = 0.1 nM) and exhibits antineoplastic activity.
Ontology: ChEBI [CHEBI:231716]  ( EBI )

Relationships
is a type of: benzamides benzenes chromones organochlorine compound primary amino compound tertiary carboxamide toluenes
has_role: antineoplastic agent apoptosis inducer microtubule-destabilising agent