Term Name: RSL3
Synonyms: (1S,3R)-RSL3, methyl (1S,3R)-2-(chloroacetyl)-1-[4-(methoxycarbonyl)phenyl]-2,3,4,4a,9,9a-hexahydro-1H-beta-carboline-3-carboxylate, ras-selective lethal small molecule 3
Definition: A beta-carboline that is 2,3,4,4a,9,9a-hexahydro-1H-beta-carboline in which the hydrogens at positions 1, 2 and 3 are replaced by 4-(methoxycarbonyl)phenyl, chloroacetyl and methoxycarbonyl groups, respectively (the 1S,2R stereoisomer). It is a potential antineoplastic agent which triggers ferroptosis by inactivating the glutathione peroxidase 4 (GPX4) enzyme.
Ontology: ChEBI [CHEBI:173109]  ( EBI )

Relationships
is a type of: benzoate ester beta-carbolines diester methyl ester organochlorine compound tertiary carboxamide
has_role: antineoplastic agent EC 1.11.1.9 (glutathione peroxidase) inhibitor ferroptosis inducer