| Name: |
non-canonical NF-kappaB signal transduction |
| Synonyms: |
NIK-IKK kinase cascade,
NIK-IKK signaling pathway,
NIK-IKK-alpha cascade,
NIK/NF-kappaB cascade,
NIK/NF-kappaB signal transduction,
NIK/NF-kappaB signaling,
non-canonical NF-KB signaling,
noncanonical NF-kappaB signaling,
noncanonical nuclear factor kappaB (NF-kappaB) pathway,
p52-dependent NF-kappaB signaling
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| Definition: |
An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF). |
| Ontology: |
GO: Biological Process [GO:0038061]
QuickGO
AmiGO
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