Phenotype Summary

Phenotypes

Publication	Data		Phenotype
Kesavan et al., 2020	Fig. 2		forebrain ism1 expression absent, abnormal forebrain neural rod ism1 expression absent, abnormal midbrain hindbrain boundary neural rod ism1 expression absent, abnormal
Gebuijs et al., 2019	Fig. 2.		ceratobranchial 5 bone bone mineralization decreased occurrence, abnormal head decreased size, abnormal parasphenoid bone mineralization decreased occurrence, abnormal
	Fig. 3		ceratohyal bone decreased length, abnormal ethmoid cartilage decreased length, abnormal head anterior region decreased width, abnormal head decreased size, abnormal Meckel's cartilage decreased length, abnormal Meckel's cartilage-palatoquadrate cartilage joint decreased width, abnormal
	Fig. 4		branchiostegal ray 1 bone mineralization decreased occurrence, abnormal ceratobranchial 5 bone bone mineralization decreased occurrence, abnormal ceratobranchial 5 tooth bone mineralization decreased occurrence, abnormal cleithrum bone mineralization decreased occurrence, abnormal entopterygoid bone mineralization decreased occurrence, abnormal notochord bone mineralization decreased occurrence, abnormal opercle bone mineralization decreased occurrence, abnormal otolith bone mineralization decreased occurrence, abnormal parasphenoid bone mineralization decreased occurrence, abnormal
	Fig. 5		whole organism col1a1a expression decreased amount, abnormal whole organism col9a1b expression decreased amount, abnormal whole organism dlx2a expression increased amount, abnormal whole organism fgf8a expression increased amount, abnormal whole organism nkx3-2 expression increased amount, abnormal whole organism runx2a expression increased amount, abnormal whole organism sp7 expression increased amount, abnormal
	Fig. 6.		whole organism dlx2a expression absent, abnormal whole organism runx2a expression increased amount, abnormal
Nittoli et al., 2019	Fig. 8		somite uncx4.1 expression increased distribution, abnormal somite uncx expression increased distribution, abnormal
Roberson et al., 2017	Fig. 5		diencephalon dorsal region dbx1b expression decreased amount, abnormal
	Fig. 6		diencephalon dorsal region ackr3b expression decreased distribution, abnormal diencephalon dorsal region cxcl12b expression decreased distribution, abnormal
Lovely et al., 2016	Fig. 9		embryonic viscerocranium morphogenesis disrupted, abnormal embryonic viscerocranium morphogenesis process quality, normal pharyngeal arch cartilage morphology, abnormal
McCarthy et al., 2016	Fig. 8		mesoderm anterior region has2 expression absent, abnormal neurocranium posterior region absent, abnormal
Akiyama et al., 2014	Fig. S1		segmental plate ab2-mapk labeling decreased amount, abnormal somitogenesis process quality, abnormal
Choe et al., 2014	Fig. 4		ceratobranchial cartilage decreased amount, abnormal pharyngeal pouch decreased amount, abnormal
Maier et al., 2014	Fig. 3		otic vesicle decreased size, abnormal posterior macula decreased size, abnormal posterior macula has fewer parts of type hair cell, abnormal
Kapsimali et al., 2011	Fig. 2		fibroblast growth factor receptor signaling pathway process quality, abnormal oral epithelium has fewer parts of type taste bud, abnormal taste bud formation decreased process quality, abnormal
Kok et al., 2010	Fig. 4		somite size, normal
Kwon et al., 2009	Fig. 1		otic vesicle agenesis, abnormal otic vesicle decreased size, abnormal otic vesicle formation process quality, abnormal otic vesicle malformed, abnormal
	Fig. 2		otic placode formation process quality, abnormal
McMahon et al., 2009	Fig. 11		retina development in camera-type eye disrupted, abnormal
Picker et al., 2009	Fig. 1		embryonic retina morphogenesis in camera-type eye decreased process quality, abnormal optic cup physical object quality, abnormal
Komisarczuk et al., 2008	Fig. 6		central nervous system development disrupted, abnormal
Marques et al., 2008	Fig. 2		heart rudiment decreased size, abnormal
Sperber et al., 2008	Fig. 8		cartilage development disrupted, abnormal determination of left/right symmetry disrupted, abnormal pharyngeal arch 3-7 morphology, abnormal
Hans et al., 2007	Fig. 5		otic vesicle decreased size, abnormal
Nechiporuk et al., 2007	Fig. 5		midbrain hindbrain boundary morphology, abnormal midbrain-hindbrain boundary development disrupted, abnormal
Plaster et al., 2007	Fig. 4		pharyngeal arch 3-7 skeleton disorganized, abnormal pharyngeal arch morphology, abnormal
	Fig. 5		post-vent region mesoderm morphology, normal post-vent region morphology, normal
	Fig. 8		post-vent region mesoderm morphology, abnormal segmental plate decreased size, abnormal
Wendl et al., 2007	Fig. 6		thyroid primordium decreased size, abnormal
Phenotype Annotation (1994-2006)	Fig. for (ti282a)		anatomical system quality, abnormal brain quality, abnormal inner ear quality, abnormal midbrain hindbrain boundary quality, abnormal midbrain quality, abnormal nervous system quality, abnormal pharyngeal arch 3-7 skeleton quality, abnormal sensory system quality, abnormal whole organism lethal (sensu genetics), abnormal
Mackereth et al., 2005	Fig. 4		otic placode physical object quality, abnormal otic vesicle decreased size, abnormal otic vesicle morphogenesis process quality, abnormal
	Fig. 7		otic vesicle decreased size, abnormal otic vesicle has fewer parts of type otolith, abnormal otic vesicle morphogenesis process quality, abnormal
Jászai et al., 2003	Fig. 1		cerebellum development disrupted, abnormal midbrain hindbrain boundary aplastic, abnormal midbrain hindbrain boundary neural rod morphology, abnormal midbrain-hindbrain boundary development disrupted, abnormal optic tectum increased size, abnormal
	Fig. 2		alar plate midbrain region morphology, abnormal midbrain hindbrain boundary neural rod morphology, abnormal midbrain morphology, abnormal midbrain neural rod morphology, abnormal midbrain-hindbrain boundary development disrupted, abnormal
	Fig. 3		cerebellum development disrupted, abnormal cerebellum morphology, abnormal midbrain hindbrain boundary aplastic, abnormal midbrain-hindbrain boundary development disrupted, abnormal
	Fig. 4		locus coeruleus aplastic, abnormal midbrain hindbrain boundary aplastic, abnormal midbrain-hindbrain boundary development disrupted, abnormal rhombomere 1 morphology, abnormal rhombomere 3 decreased thickness, abnormal rhombomere 5 decreased thickness, abnormal rostrocaudal neural tube patterning disrupted, abnormal
	Fig. 5		apoptotic process increased occurrence, abnormal apoptotic process occurrence, normal cell population proliferation occurrence, normal cell proliferation in hindbrain disrupted, abnormal cell proliferation in midbrain disrupted, abnormal hindbrain apoptotic, abnormal optic tectum apoptotic, abnormal
Lam et al., 2003	Fig. 6		forebrain neuron normal amount, normal forebrain neuron spatial pattern, normal locus coeruleus neuron decreased amount, abnormal
Adamska et al., 2000	Fig. 3		otic vesicle hmx3a expression decreased amount, abnormal statoacoustic (VIII) ganglion hmx3a expression absent, abnormal
Reifers et al., 2000	Fig. 1		anterior cardinal vein absent, abnormal blood circulation decreased functionality, abnormal blood vessel development process quality, normal blood vessel endothelial cell present, normal blood vessel organization quality, normal brain vasculature dorsal region absent, abnormal cardiac ventricle decreased length, abnormal cardiac ventricle hypotrophic, abnormal endocardium present, normal heart decreased length, abnormal heart development process quality, abnormal heart dysplastic, abnormal heart morphology, abnormal hindbrain blood vessel absent, abnormal intersegmental vessel absent, abnormal midbrain hindbrain boundary blood vessel absent, abnormal myocardium present, normal optic tectum blood vessel absent, abnormal pharyngeal arch blood vessel absent, abnormal
Guo et al., 1999	Fig. 6		locus ceruleus development disrupted, abnormal locus coeruleus absent, abnormal
Heisenberg et al., 1999	Fig. 9		cerebellum aplastic, abnormal
Reifers et al., 1998	Fig. 10		intermediate mesoderm differentiated, normal somite development decreased process quality, abnormal somite poorly differentiated, abnormal
	Fig. 11		embryonic pectoral fin morphogenesis process quality, normal pectoral fin bud morphology, normal
	Fig. 7		cerebellum development decreased process quality, abnormal midbrain-hindbrain boundary development decreased process quality, abnormal whole organism lacks all parts of type cerebellum, abnormal whole organism lacks all parts of type midbrain hindbrain boundary, abnormal
	Fig. 8		midbrain hindbrain boundary physical object quality, abnormal midbrain-hindbrain boundary development decreased process quality, abnormal
Brand et al., 1996	Fig. 1		blood circulation disrupted, abnormal cerebellum absent, abnormal midbrain hindbrain boundary absent, abnormal optic tectum increased size, abnormal
	Fig. 7		cerebellum absent, abnormal inner ear decreased size, abnormal midbrain hindbrain boundary absent, abnormal midbrain neural rod increased thickness, abnormal midbrain neural rod prominent, abnormal optic tectum increased size, abnormal otolith organ has fewer parts of type otolith, abnormal semicircular canal truncated, abnormal
	Fig. 8		cerebellum aplastic, abnormal midbrain hindbrain boundary aplastic, abnormal optic tectum increased size, abnormal tegmentum morphology, abnormal
Brand et al., 1996	Table 1		post-vent region curved ventral, abnormal retinal ganglion cell axon guidance disrupted, abnormal
Whitfield et al., 1996	Table 3		inner ear decreased size, abnormal inner ear has fewer parts of type otolith, abnormal