- Title
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Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation
- Authors
- McCarroll, M.N., Gendelev, L., Kinser, R., Taylor, J., Bruni, G., Myers-Turnbull, D., Helsell, C., Carbajal, A., Rinaldi, C., Kang, H.J., Gong, J.H., Sello, J.K., Tomita, S., Peterson, R.T., Keiser, M.J., Kokel, D.
- Source
- Full text @ Nat. Commun.
GABAAR PAMs enhance acoustic startle in zebrafish. Zebrafish were treated with the indicated compounds and analyzed for changes in behavioral responses. |
A high-throughput behavioral screen identifies GABAergic compounds. Zebrafish were treated with various compounds and analyzed for anesthetic-related behaviors. |
Hit compounds activate hindbrain neurons. Animals were exposed to the indicated drugs and stimuli and analyzed for pERK levels as a readout of neuronal activity. |