FIGURE SUMMARY
Title

Individual knock out of glycine receptor alpha subunits identifies a specific requirement of glra1 for motor function in zebrafish

Authors
Samarut, E., Chalopin, D., Riché, R., Allard, M., Liao, M., Drapeau, P.
Source
Full text @ PLoS One
Fig 5

Morphology and swimming activity of GlyR alpha subunit knockouts.

A, For each knock-out, the embryos developed normally and no abnormal morphology was observed at 48 hpf. B, However, when their swimming activity was assessed at 5 dpf during 4h/4h dark/light condition, hic (glra1-/-) mutant larvae depicted a decreased activity with no startle response to light compared to their siblings. No difference was observed for the other knockout lines.
Fig 6

Hic mutants display motor coordination dysfunction.

A, Touch-evoked escape response of hitch mutants versus their siblings at 7 dpf show a dysfunction of motor coordination of hic-/- larvae. Indeed, hic-/- larvae are not able to bend their tail in a coordinated manner in order to initiate an escape swimming response (see S1 and S2 Movies for full recordings). B, Hic-/- larvae at 7 dpf show a reduction of the trunk size as well as defects of the notochord and a change in birefringence of trunk muscles. C, Measurement of the trunk size at different age shows that the reduction in trunk length starts at 3 dpf and aggravates at 7 dpf presumably due to the motor dysfunction.
text only

Unillustrated author statements

EXPRESSION / LABELING:
Genes:
Fish:
Anatomical Term:
Stage Range: 8-cell to Days 7-13
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One
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