FIGURE SUMMARY
- Title
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Loss of PRP4K drives anoikis resistance in part by dysregulation of epidermal growth factor receptor endosomal trafficking
- Authors
- Corkery, D.P., Clarke, L.E., Gebremeskel, S., Salsman, J., Pinder, J., Le Page, C., Meunier, L., Xu, Z., Mes-Masson, A.M., Berman, J.N., Johnston, B., Dellaire, G.
- Source
- Full text @ Oncogene
Knockdown of PRP4K increases ID8 proliferation in a zebrafish xenotransplantation model. (a) Representative brightfield, fluorescent and merged images are shown for zebrafish embryos at 24 and 72 h post injection (hpi) with either ID8 shCTRL or ID8 shPRP4K-1 cells. (b) ID8 shCTRL and shPRP4K-1 engrafted embryos were dissociated at 24 and 72 hpi and the number of fluorescent cells counted. The fold change in cell number was determined and represented as a scatterplot with each point representing an independent experiment. Pooled groups of 15–20 embryos were used for each data point. Error bars=s.d. *P<0.05. |
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Full text @ Oncogene