FIGURE SUMMARY
Title

The psychoactive drug 25B-NBOMe recapitulates rhabdomyolysis in zebrafish larvae

Authors
Kawahara, G., Maeda, H., Kikura-Hanajiri, R., Yoshida, K.I., Hayashi, Y.K.
Source
Full text @ Forensic Toxicol

a Survival rates of zebrafish larvae as a function of 25B-NBOMe concentrations, treated or untreated for 2 days. The asterisk shows the significant difference between vehicle and 0.5 μg/mL 25B-NBOMe groups (p = 0.00000458). b Microscopic photographs of zebrafish larvae untreated and treated with 0.5 μg/mL 25B-NBOMe. c Ratio of zebrafish larvae with reduced muscle birefringence (BR) after treatment with 0.5 μg/mL 25B-NBOMe and no treatment

Microscopic immunofluorescent photographs after immunostaining for β-dystroglycan and myosin heavy chain in skeletal muscle of zebrafish larvae with and without treatment by 25B-NBOMe at 0.5 μg/mL for 2 days. The arrowhead and arrow in the right upper panel show irregularity and disruption of the myosepta, respectively. The arrows shown in the right lower panel show myofibril injuries inflicted by 25B-NBOMe. The bar shows the length of 50 μm

PHENOTYPE:
Fish:
Condition:
Observed In:
Stage: Day 6

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Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Forensic Toxicol