- Title
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The psychoactive drug 25B-NBOMe recapitulates rhabdomyolysis in zebrafish larvae
- Authors
- Kawahara, G., Maeda, H., Kikura-Hanajiri, R., Yoshida, K.I., Hayashi, Y.K.
- Source
- Full text @ Forensic Toxicol
a Survival rates of zebrafish larvae as a function of 25B-NBOMe concentrations, treated or untreated for 2 days. The asterisk shows the significant difference between vehicle and 0.5 μg/mL 25B-NBOMe groups (p = 0.00000458). b Microscopic photographs of zebrafish larvae untreated and treated with 0.5 μg/mL 25B-NBOMe. c Ratio of zebrafish larvae with reduced muscle birefringence (BR) after treatment with 0.5 μg/mL 25B-NBOMe and no treatment |
Microscopic immunofluorescent photographs after immunostaining for β-dystroglycan and myosin heavy chain in skeletal muscle of zebrafish larvae with and without treatment by 25B-NBOMe at 0.5 μg/mL for 2 days. The arrowhead and arrow in the right upper panel show irregularity and disruption of the myosepta, respectively. The arrows shown in the right lower panel show myofibril injuries inflicted by 25B-NBOMe. The bar shows the length of 50 μm PHENOTYPE:
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