- Title
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RSK1 Activation Promotes Invasion in Nodular Melanoma
- Authors
- Salhi, A., Farhadian, J.A., Giles, K.M., Vega-Saenz de Miera, E., Silva, I.P., Bourque, C., Yeh, K., Chhangawala, S., Wang, J., Ye, F., Zhang, D.Y., Hernando-Monge, E., Houvras, Y., Osman, I.
- Source
- Full text @ Am. J. Pathol.
Constitutive activation of protein S6 kinase, 90 kDa, polypeptide 1 (RSK1) accelerates melanoma tumor onset and invasion in zebrafish. A: Melanoma-free survival curve of miniCoopR-green fluorescent protein (GFP)-, miniCoopR-Myr-RSK1-, and miniCoopR-RSK-deltaCCT-injected zebrafish. B: Histologic sections of zebrafish RSK1dCCT- and Myr-RSK1-expressing melanomas were stained with hematoxylin and eosin to assess tumor invasion depth. Arrows indicate muscular invasion by melanoma cells. C: Depth of invasion was measured for each tumor and was quantified by averaging the depth of invasion of four tumors for each group (RSK1dCCT and Myr-RSK1). Data are given as means ± SEM. ***P < 0.001 compared with dominant-negative RSK1-expressing tumors. |