FIGURE SUMMARY
Title

Mutations in the interleukin receptor IL11RA cause autosomal recessive Crouzon-like craniosynostosis

Authors
Keupp, K., Li, Y., Vargel, I., Hoischen, A., Richardson, R., Neveling, K., Alanay, Y., Uz, E., Elciolu, N., Rachwalski, M., Kamaci, S., Tunçbilek, G., Akin, B., Grötzinger, J., Konas, E., Mavili, E., Müller-Newen, G., Collmann, H., Roscioli, T., Buckley, M.F., Yigit, G., Gilissen, C., Kress, W., Veltman, J., Hammerschmidt, M., Akarsu, N.A., and Wollnik, B.
Source
Full text @ Mol. Genet. Genomic Med.

Il11ra expression in mouse and zebrafish sutures. (A-B) Sagittal cryosections of P0 mouse heads; scale bars: 100µm. (A) Upper row, histological staining with hematoxylin and eosin shows the coronal suture (arrow heads) and surrounding tissue. Lower row, immunofluorescence staining displays Il11ra localization (red) in the granular layer of the skin (arrow) and around the coronal suture tips (asterisks). Nuclei were stained with DAPI (blue). White lines mark cranial bone plates. (B) Immunofluorescence staining of Il11ra (red) shows protein in the lambdoidal suture (asterisks). Nuclei were stained with DAPI (blue). White lines mark cranial bone plates. (C) In situ hybridization of il11ra mRNA on sagittal paraffin sections of adult zebrafish heads. il11ra is expressed within the coronal sutures (left) and anteriorly in craniofacial bone fusions (right, arrows) within areas of bone contact; scale bars: 100µm.

EXPRESSION / LABELING:
Gene:
Fish:
Anatomical Terms:
Stage: Adult
Acknowledgments
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