FIGURE SUMMARY
Title

Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopy

Authors
Lorent, K., Yeo, S.Y., Oda, T., Chandrasekharappa, S., Chitnis, A., Matthews, R.P., and Pack, M.
Source
Full text @ Development

Liver expression of zebrafish jagged and notch genes. (A-C) Lateral view of wild-type 72-hpf larvae processed for RNA in situ hybridization using jagged 1 (A), jagged 2 (B) and jagged 3 (C) antisense probes. All three jagged genes are expressed in the larval liver (arrow), but jagged 2 expression is most pronounced. Expression in the branchial arches is also evident. (D-G) Lateral view of wild-type 72-hpf larvae processed for RNA in situ hybridization using notch 1a (D), notch 1b (E), notch 2 (F) and notch 5 (G) probes. All notch genes are expressed in the developing larval liver and the branchial arches.

Acknowledgments
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