ZFIN ID: ZDB-EXP-201005-1
Experiment Conditions Description: perforation: retina, chemical treatment by injection: sirolimus
perforation: retina
Name: perforation
Synonyms:
Definition: Experimental condition in which a hole or break in the membranes of an organ or structure of the body is created.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000178]
Name: retina
Synonyms: retinas
Definition: Multi-tissue structure that contains the retinal neural layer and the retinal pigmented epithelium, and develops from the optic cup.
Ontology: Anatomy Ontology [ZFA:0000152]
chemical treatment by injection: sirolimus
Name: chemical treatment by injection
Synonyms:
Definition: Chemical treatment in which the chemical is injected into the zebrafish.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000237]
Name: sirolimus
Synonyms: (-)-Rapamycin, (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-{(2S)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0(4,9)]hexatriaconta-16,24,26,28-tet, (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-ep, Antibiotic AY 22989, Rapamune, rapamycin, sirolimus, sirolimusum
Definition: A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Ontology: Chebi [CHEBI:9168]
Publication: Zhang et al., 2019